In the FNAC technique, equipment involved glass slides, cover slips, antiseptics, disposable gloves, fixative absolute ethyl alcohol ,swabs, 23 French Fr gauge hypodermic needles 23Fr, 24Fr, 25 Fr is recommended and 10 ml syringes. Methods Patients who underwent clinical and laboratory evaluation and thyroidectomy at Mulago National Referral hospital and the Pathology department of Makerere University College of Health Sciences were consecutively recruited over a four months period. Thyroidectomy specimen was evaluated by histopathological examination. Table 1 Social demographic characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm. This article has been cited by other articles in PMC. J Egypt Natl Canc Inst.

Ihtesham uddin Qureshi 3 Prof. The results were quite similar to the results of a study conducted by Herraiz et al. Comparison of results of present study with previous studies. Consecutive sampling was used. Photomicrograph showing negative control for Galectin-3staining in thyroid follicular cells on FNAC X, Photomicrograph showing Positive control for Galectin-3staining in Anaplastic large cell lymphoma X, Photomicrograph showing strong positive Galectin-3staining in thyroid follicular cells on FNAC and Photomicrograph showing weak positive Galectin-3staining in thyroid follicular cells on FNAC. Paraffin embedded cellblocks were kept for Galectin-3immunostaining. Are solitary thyroid nodules more likely to be malignant?

AM was the main author who did her MPhil research on this topic.

Journal of Thyroid Research

The attending cytopathologist examined the smears for standard adequate amount of follicular cells for cytodiagnosis. In a related study in Uganda, FTC predominated at FNAC is cost-effective, minimally invasive and highly accurate for investigating patients with thyroid cancer.


Table 1 Social demographic characteristics of patients who underwent thyroidectomy at Mulago Hospital during the study period prospective arm. Rosai J, Ackerman LV. These findings give good preliminary data on performance of FNAC in thyroid disease in our setting.

thesis on thyroid fnac

Background The most common endocrine malignancy is thyroid carcinoma. Interviews were conducted with all fully consenting patients using a standard pretested questionnaire aimed at capturing patients’ history, examination and investigation findings.

thesis on thyroid fnac

The many pathologists involved in reporting histopathology could have over-estimated or under-estimated malignancy thyroi random error. Thyroid carcinoma constitutes for 0. Fine needle aspiration cytology is considered the gold standard diagnostic test for the diagnosis of thyroid nodules.

M ratio was Quality control was assured by maintaining that FNB procurement, processing and reporting was done by experienced cytopathologists using the Bethesda system for reporting thyroid cytopathologythe histopathologist examining excised thyroid specimens was blinded to preoperative diagnosis with FNAC and the cytopathologists and histopathologists for FNAC and histopathology of excised specimens respectively were generally the same for both the retrospective and prospective arms of the study thus minimizing inter-observer bias.

The Bethesda system for reporting thyroid cytopathology. Methods in observational epidemiology. Solitary thyroid nodule is defined clinically as the localised thyroid enlargement with apparently normal rest of the gland.

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Diagnostic fhac of fine needle aspiration cytology in thyroid lesions. Major issues are the gray-zoned cases i. Incidental cancer in patients surgically treated for benign thyroid disease. The aim of this study was to estimate the sensitivity and specificity of FNAC in detecting malignancy for thyroid disease using histopathology as the gold standard.


FNAC is considered the gold standard diagnostic test in the evaluation of a thyroid nodule, and other tests like ultrasound and nuclear scan should be used thrsis conjunction with FNAC.

Open in a separate window. After processing, tissue embedding was done using paraffin wax. The main aim of FNAC is to identify nodules that require surgery and those benign nodules that can be observed clinically and decrease the overall thyroidectomy rate in patients with benign diseases.

The Accuracy of Manual Fine Needle Aspiration Cytology in the Evaluation of Thyroid Cancer

Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were calculated for neoplastic and carcinomatous lesions. Galectin-3 immunostaining in cytological and histopathological diagnosis of thyroid lesions. Inclusion criteria included clinically detected solitary thyroid nodule and euthyroid patients with normal thyroid function tests. The accuracy rate was recorded as Study design This was a retrospective study.

Fischer S, Thuroid SL. Fine needle aspiration cytology is a cost effective procedure that provides specific diagnosis rapidly with minimal complications.

We were unable to achieve the estimated sample size within the study period. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were